Assay Detail
Functional
CHEMBL654822
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Inhibitory activity against HIV-1 IIIB replication in C8166 cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.00 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102192 | — | — | 1 | 7.92 |
| CHEMBL319091 | — | — | 1 | 7.60 |
| CHEMBL100934 | — | — | 1 | 7.41 |
| CHEMBL321544 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102192 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL319091 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL100934 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL321544 | — | IC50 | = | 9000.0 | nM | 5.05 |