Assay Detail
Functional
CHEMBL654858
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Inhibition of ADP induced human blood platelet aggregation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.98 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202698 | — | — | 1 | 5.68 |
| CHEMBL1202699 | — | — | 1 | 5.68 |
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 5.60 |
| CHEMBL1202700 | — | — | 1 | 5.55 |
| CHEMBL1202701 | — | — | 1 | 5.22 |
| CHEMBL299486 | — | — | 1 | 4.64 |
| CHEMBL55957 | — | — | 1 | 4.38 |
| CHEMBL301293 | — | — | 1 | 4.06 |
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202698 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1202699 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL477 | ADENOSINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1202700 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1202701 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL299486 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL55957 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL301293 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 97000.0 | nM | 4.01 |