Assay Detail
Binding
CHEMBL654882
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Compound was evaluated for the in vitro inhibition of the Butyrylcholinesterase from horse serum
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.26 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.22 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 7.14 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.54 |
| CHEMBL93936 | — | — | 1 | 5.33 |
| CHEMBL92736 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL93936 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL92736 | — | IC50 | = | 9000.0 | nM | 5.05 |