Assay Detail
Binding
CHEMBL654883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of (BChE) Butyrylcholinesterase of horse serum
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex) derivaties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.51 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62084 | — | — | 1 | 9.15 |
| CHEMBL431844 | — | — | 1 | 8.89 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.29 |
| CHEMBL292314 | — | — | 1 | 8.10 |
| CHEMBL134057 | — | — | 1 | 7.90 |
| CHEMBL368196 | — | — | 1 | 7.82 |
| CHEMBL172118 | — | — | 1 | 7.77 |
| CHEMBL352500 | — | — | 1 | 7.66 |
| CHEMBL369661 | — | — | 1 | 7.35 |
| CHEMBL51934 | VELNACRINE | 2.0 | 1 | 7.27 |
| CHEMBL355740 | — | — | 1 | 6.68 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.38 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62084 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL431844 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL95 | TACRINE | IC50 | = | 5.17 | nM | 8.29 |
| CHEMBL292314 | — | IC50 | = | 7.93 | nM | 8.10 |
| CHEMBL134057 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL368196 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL172118 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL352500 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL369661 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL51934 | VELNACRINE | IC50 | = | 53.3 | nM | 7.27 |
| CHEMBL355740 | — | IC50 | = | 206.7 | nM | 6.68 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 4166.7 | nM | 5.38 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 4666.7 | nM | 5.33 |