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Assay Detail

CHEMBL654916

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Binding
Inhibitory activity against Escherichia coli TEM-3 Beta-lactamase
ChEMBL ↗
35
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Beta-lactamase (CHEMBL2026) ↗
Type SINGLE PROTEIN
Organism Escherichia coli K-12

Publication

Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.
Heinze-Krauss I, Angehrn P, Charnas RL, Gubernator K, Gutknecht EM, Hubschwerlen C, Kania M, Oefner C, Page MG, Sogabe S, Specklin JL, Winkler F.
J Med Chem (1998) 41 : 3961 -3971
PubMed 9767633 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 5.99 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL777 CLAVULANIC ACID 4.0 2 7.82
CHEMBL127782 — — 2 7.51
CHEMBL340707 — — 1 7.46
CHEMBL340351 — — 2 6.29
CHEMBL2079714 — — 1 6.16
CHEMBL338157 — — 2 5.40
CHEMBL338933 — — 2 4.10
CHEMBL130187 — — 2 4.00
CHEMBL341484 — — 2 -
CHEMBL129090 — — 2 -
CHEMBL336630 — — 1 -
CHEMBL338351 — — 1 -
CHEMBL130854 — — 1 -
CHEMBL129226 — — 2 -
CHEMBL341496 — — 2 -
CHEMBL339600 — — 2 -
CHEMBL129651 — — 2 -
CHEMBL415234 — — 1 -
CHEMBL128523 — — 1 -
CHEMBL340423 — — 2 -
CHEMBL340937 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL777 CLAVULANIC ACID IC50 = 15.0 nM 7.82
CHEMBL777 CLAVULANIC ACID IC50 = 15.0 nM 7.82
CHEMBL127782 — IC50 = 31.0 nM 7.51
CHEMBL127782 — IC50 = 31.0 nM 7.51
CHEMBL340707 — IC50 = 35.0 nM 7.46
CHEMBL340351 — IC50 = 511.0 nM 6.29
CHEMBL340351 — IC50 = 511.0 nM 6.29
CHEMBL2079714 — IC50 = 700.0 nM 6.16
CHEMBL338157 — IC50 = 4000.0 nM 5.40
CHEMBL338157 — IC50 = 4000.0 nM 5.40
CHEMBL338933 — IC50 = 79200.0 nM 4.10
CHEMBL338933 — IC50 = 79200.0 nM 4.10
CHEMBL130187 — IC50 = 100000.0 nM 4.00
CHEMBL130187 — IC50 = 100000.0 nM 4.00
CHEMBL340423 — IC50 > 100000.0 nM -
CHEMBL340423 — IC50 > 100000.0 nM -
CHEMBL128523 — IC50 > 100000.0 nM -
CHEMBL340937 — IC50 > 100000.0 nM -
CHEMBL415234 — IC50 > 100000.0 nM -
CHEMBL129651 — IC50 > 100000.0 nM -
CHEMBL129651 — IC50 > 100000.0 nM -
CHEMBL339600 — IC50 > 100000.0 nM -
CHEMBL339600 — IC50 > 100000.0 nM -
CHEMBL341496 — IC50 > 100000.0 nM -
CHEMBL340937 — IC50 > 100000.0 nM -
CHEMBL129226 — IC50 > 100000.0 nM -
CHEMBL129226 — IC50 > 100000.0 nM -
CHEMBL130854 — IC50 > 100000.0 nM -
CHEMBL338351 — IC50 > 100000.0 nM -
CHEMBL336630 — IC50 > 100000.0 nM -
CHEMBL129090 — IC50 > 100000.0 nM -
CHEMBL129090 — IC50 > 100000.0 nM -
CHEMBL341484 — IC50 > 100000.0 nM -
CHEMBL341484 — IC50 > 100000.0 nM -
CHEMBL341496 — IC50 > 100000.0 nM -