Assay Detail
Binding
CHEMBL655026
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Inhibition of Equine Butyrylcholinesterase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.89 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129108 | — | — | 1 | 9.40 |
| CHEMBL131410 | — | — | 1 | 8.70 |
| CHEMBL32823 | — | — | 1 | 8.70 |
| CHEMBL338755 | — | — | 1 | 8.22 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.15 |
| CHEMBL129719 | — | — | 1 | 8.00 |
| CHEMBL131386 | — | — | 1 | 7.96 |
| CHEMBL51197 | — | — | 1 | 7.46 |
| CHEMBL48643 | — | — | 1 | 7.30 |
| CHEMBL51350 | — | — | 1 | 6.75 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 6.19 |
| CHEMBL53927 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129108 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL131410 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL32823 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL338755 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL95 | TACRINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL129719 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL131386 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL51197 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL48643 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL51350 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL502 | DONEPEZIL | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL53927 | — | Ki | > | 20000.0 | nM | - |