Assay Detail
Binding
CHEMBL655036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of Pseudomonas aeruginosa 18SH, class C of Beta-lactamase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Beta-lactamase (CHEMBL5031) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.02 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333330 | — | — | 1 | 6.27 |
| CHEMBL332565 | — | — | 1 | 5.05 |
| CHEMBL122209 | — | — | 1 | 4.82 |
| CHEMBL121924 | — | — | 1 | 4.82 |
| CHEMBL123481 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333330 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL332565 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL122209 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL121924 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL123481 | — | IC50 | = | 75000.0 | nM | 4.12 |