Assay Detail
Functional
CHEMBL655048
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The compound was tested for inhibition against HIV-III B from C8 166 cell lines.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.01 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137838 | — | — | 1 | 5.22 |
| CHEMBL336441 | — | — | 1 | 5.14 |
| CHEMBL329653 | — | — | 1 | 5.00 |
| CHEMBL138969 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137838 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL336441 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL329653 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL138969 | — | IC50 | = | 20500.0 | nM | 4.69 |