Assay Detail

CHEMBL655050

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Functional

Inhibitory concentration against HIV-2 rod strain in acutely infected C8166 T cells

ChEMBL ↗

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Target

C8166 (CHEMBL614533) ↗

Open DB target context

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C8166 (CHEMBL614533) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target C8166

CHEMBL614533

Anchored from Assay target.

Protein identity C8166

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	C8166
Confidence	1 — Organism
Curated By	Intermediate

Target

C8166 (CHEMBL614533) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.

Beaulieu PL, Wernic D, Abraham A, Anderson PC, Bogri T, Bousquet Y, Croteau G, Guse I, Lamarre D, Liard F, Paris W, Thibeault D, Pav S, Tong L.
J Med Chem (1997) 40 : 2164 -2176
PubMed 9216835 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	7.60	7.60

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL13134	PALINAVIR	2.0	1	7.60

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL13134	PALINAVIR	EC50	=	25.0	nM	7.60