Assay Detail
Functional
CHEMBL655051
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Ability to inhibit the replication of HIV-1 IIIB infected C8166 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phosphate derivatives of d4T as inhibitors of HIV
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.94 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.10 |
| CHEMBL277071 | — | — | 1 | 6.70 |
| CHEMBL279534 | — | — | 1 | 6.40 |
| CHEMBL274008 | — | — | 1 | 4.82 |
| CHEMBL19243 | — | — | 1 | 4.70 |
| CHEMBL19750 | — | — | 1 | - |
| CHEMBL19745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL991 | STAVUDINE | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL277071 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL279534 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL274008 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL19243 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL19750 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL19745 | — | EC50 | = | 200000.0 | nM | - |