Assay Detail
Binding
CHEMBL655073
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Beta-Trypsin inhibitory activity of compound was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.50 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124809 | — | — | 1 | 9.00 |
| CHEMBL340098 | — | — | 1 | 8.70 |
| CHEMBL127185 | — | — | 1 | 8.40 |
| CHEMBL339703 | — | — | 1 | 8.30 |
| CHEMBL341148 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124809 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL340098 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL127185 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL339703 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL341148 | — | IC50 | = | 8.0 | nM | 8.10 |