Assay Detail
Functional
CHEMBL655350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to achieve 50% inhibition of HIV-1 LAI replication in human T4 lymphoblastoid CEM-SS cells.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 5.71 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.70 |
| CHEMBL57733 | — | — | 1 | 7.77 |
| CHEMBL58213 | — | — | 1 | 7.60 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 7.51 |
| CHEMBL20610 | — | — | 1 | 6.37 |
| CHEMBL417227 | — | — | 1 | 6.14 |
| CHEMBL56328 | — | — | 1 | 6.10 |
| CHEMBL440482 | — | — | 1 | 5.77 |
| CHEMBL58914 | — | — | 1 | 5.55 |
| CHEMBL58497 | — | — | 1 | 5.50 |
| CHEMBL57161 | — | — | 1 | 5.48 |
| CHEMBL418119 | — | — | 1 | 5.35 |
| CHEMBL417953 | — | — | 1 | 5.11 |
| CHEMBL58653 | — | — | 1 | 4.70 |
| CHEMBL57301 | — | — | 1 | 4.62 |
| CHEMBL57590 | — | — | 1 | 4.60 |
| CHEMBL301685 | — | — | 1 | 4.48 |
| CHEMBL292392 | — | — | 1 | 4.38 |
| CHEMBL57929 | — | — | 1 | 4.24 |
| CHEMBL418294 | — | — | 1 | 4.16 |
| CHEMBL58891 | — | — | 1 | - |
| CHEMBL300607 | — | — | 1 | - |
| CHEMBL57313 | — | — | 1 | - |
| CHEMBL418118 | — | — | 1 | - |
| CHEMBL262003 | — | — | 1 | - |
| CHEMBL60873 | — | — | 1 | - |
| CHEMBL59514 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL57733 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL58213 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL20610 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL417227 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL56328 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL440482 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL58914 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL58497 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL57161 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL418119 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL417953 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL58653 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL57301 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL57590 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL301685 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL292392 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL57929 | — | EC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL418294 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL58891 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL300607 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL57313 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL418118 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL262003 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL60873 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL59514 | — | EC50 | > | 10000.0 | nM | - |