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Assay Detail

CHEMBL655427

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Binding
Binding affinity against carboxypeptidase A using hippurylphenylalanine as substrate
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carboxypeptidase A1 (CHEMBL3481)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

The structural feature of S1 subsite of carboxypeptidase A
Kim DH, Shin YS, Kim KB
Bioorg Med Chem Lett (1991) 1 : 317 -322
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.54 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL58957 1 7.96
CHEMBL325373 1 7.46
CHEMBL109520 1 7.43
CHEMBL323484 1 7.35
CHEMBL111288 1 6.95
CHEMBL325984 1 6.92
CHEMBL322812 1 6.77
CHEMBL110056 1 6.70
CHEMBL108812 1 6.60
CHEMBL111619 1 6.46
CHEMBL323749 1 6.32
CHEMBL108489 1 6.31
CHEMBL108486 1 6.23
CHEMBL108756 1 5.64
CHEMBL109402 1 5.63
CHEMBL111511 1 5.35
CHEMBL320355 1 5.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL58957 Ki = 11.0 nM 7.96
CHEMBL325373 Ki = 35.0 nM 7.46
CHEMBL109520 Ki = 37.0 nM 7.43
CHEMBL323484 Ki = 45.0 nM 7.35
CHEMBL111288 Ki = 112.0 nM 6.95
CHEMBL325984 Ki = 120.0 nM 6.92
CHEMBL322812 Ki = 170.0 nM 6.77
CHEMBL110056 Ki = 200.0 nM 6.70
CHEMBL108812 Ki = 250.0 nM 6.60
CHEMBL111619 Ki = 350.0 nM 6.46
CHEMBL323749 Ki = 480.0 nM 6.32
CHEMBL108489 Ki = 492.0 nM 6.31
CHEMBL108486 Ki = 590.0 nM 6.23
CHEMBL108756 Ki = 2300.0 nM 5.64
CHEMBL109402 Ki = 2350.0 nM 5.63
CHEMBL111511 Ki = 4500.0 nM 5.35
CHEMBL320355 Ki = 7700.0 nM 5.11