Assay Detail
Binding
CHEMBL655428
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Inhibition of bovine carboxypeptidase A (CPA) using hippuryl-L-phenylalanine (Hipp-L-Phe) as a substrate.
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Cysteine derivatives as inhibitors for carboxypeptidase A: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 5.88 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58957 | — | — | 1 | 8.00 |
| CHEMBL171617 | — | — | 1 | 7.26 |
| CHEMBL367332 | — | — | 1 | 7.19 |
| CHEMBL354045 | — | — | 1 | 6.80 |
| CHEMBL354680 | — | — | 1 | 6.72 |
| CHEMBL169182 | — | — | 1 | 6.57 |
| CHEMBL174406 | — | — | 1 | 6.25 |
| CHEMBL173767 | — | — | 1 | 6.21 |
| CHEMBL174116 | — | — | 1 | 6.09 |
| CHEMBL174065 | — | — | 1 | 6.07 |
| CHEMBL355775 | — | — | 1 | 5.96 |
| CHEMBL174127 | — | — | 1 | 5.89 |
| CHEMBL174367 | — | — | 1 | 5.89 |
| CHEMBL172116 | — | — | 1 | 5.87 |
| CHEMBL170680 | — | — | 1 | 5.85 |
| CHEMBL173587 | — | — | 1 | 5.68 |
| CHEMBL171281 | — | — | 1 | 5.64 |
| CHEMBL109402 | — | — | 1 | 5.63 |
| CHEMBL354627 | — | — | 1 | 5.62 |
| CHEMBL172986 | — | — | 1 | 5.54 |
| CHEMBL366555 | — | — | 1 | 5.54 |
| CHEMBL424568 | — | — | 1 | 5.26 |
| CHEMBL170775 | — | — | 1 | 5.25 |
| CHEMBL172319 | — | — | 1 | 5.12 |
| CHEMBL173967 | — | — | 1 | 5.10 |
| CHEMBL171190 | — | — | 1 | 5.03 |
| CHEMBL173916 | — | — | 1 | 5.02 |
| CHEMBL367910 | — | — | 1 | 4.92 |
| CHEMBL170308 | — | — | 1 | 4.48 |
| CHEMBL863 | CYSTEINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58957 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL171617 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL367332 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL354045 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL354680 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL169182 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL174406 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL173767 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL174116 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL174065 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL355775 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL174127 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL174367 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL172116 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL170680 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL173587 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL171281 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL109402 | — | Ki | = | 2350.0 | nM | 5.63 |
| CHEMBL354627 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL172986 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL366555 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL424568 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL170775 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL172319 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL173967 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL171190 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL173916 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL367910 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL170308 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL863 | CYSTEINE | Ki | = | 350000.0 | nM | - |
| CHEMBL367185 | — | Ki | > | 500000.0 | nM | - |