Assay Detail
Binding
CHEMBL655449
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In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasma
13
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.45 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68399 | — | — | 2 | 8.57 |
| CHEMBL149680 | — | — | 1 | 8.22 |
| CHEMBL150332 | — | — | 1 | 8.09 |
| CHEMBL436425 | — | — | 1 | 7.68 |
| CHEMBL302067 | — | — | 3 | 7.46 |
| CHEMBL358017 | — | — | 1 | 7.44 |
| CHEMBL344949 | — | — | 1 | 7.30 |
| CHEMBL356252 | — | — | 1 | 7.28 |
| CHEMBL151284 | — | — | 1 | 5.80 |
| CHEMBL33352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68399 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL68399 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL149680 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL150332 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL436425 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL302067 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL358017 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL344949 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL356252 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL302067 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL302067 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL151284 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL33352 | — | IC50 | > | 100000.0 | nM | - |