Assay Detail
Binding
CHEMBL655465
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[Ca2+] channel binding affinity was evaluated by its ability to displace [3H]-PN-200-110 in rat brain synaptosomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Preparation and in vitro biological evaluation of the enantiomers of the diydropyridine BMY 20014, a combination calcium and 1-adrenoreceptor antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.64 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 9.28 |
| CHEMBL2111202 | — | — | 1 | 8.11 |
| CHEMBL3301661 | — | — | 1 | 7.80 |
| CHEMBL151910 | — | — | 1 | 7.46 |
| CHEMBL2111260 | — | — | 1 | 6.74 |
| CHEMBL2115538 | — | — | 1 | 6.47 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL2111202 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL3301661 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL151910 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL2111260 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL2115538 | — | Ki | = | 338.0 | nM | 6.47 |
| CHEMBL2 | PRAZOSIN | Ki | > | 1000.0 | nM | - |