Assay Detail
Functional
CHEMBL655556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity in CEM/TK cell line infected with HIV-1 and Concentration required to inhibit the replication of HIV-1 by 50% was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-TK(+) |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.55 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418469 | — | — | 1 | 7.31 |
| CHEMBL129229 | — | — | 1 | 6.59 |
| CHEMBL340610 | — | — | 1 | 6.50 |
| CHEMBL291344 | — | — | 1 | 6.35 |
| CHEMBL262678 | — | — | 1 | 6.28 |
| CHEMBL126557 | — | — | 1 | 6.26 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418469 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL129229 | — | EC50 | = | 255.0 | nM | 6.59 |
| CHEMBL340610 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL291344 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL262678 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL126557 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL129 | ZIDOVUDINE | EC50 | > | 100000.0 | nM | - |