Assay Detail
Binding
CHEMBL655562
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IC50 against recombinant human Prostaglandin G/H synthase 2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.35 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7162 | NS-398 | — | 1 | 6.72 |
| CHEMBL15945 | — | — | 1 | 6.58 |
| CHEMBL274990 | SC-58125 | — | 1 | 6.51 |
| CHEMBL276506 | — | — | 1 | 6.24 |
| CHEMBL295739 | — | — | 1 | 5.82 |
| CHEMBL277721 | — | — | 1 | 5.82 |
| CHEMBL15791 | — | — | 1 | 5.77 |
| CHEMBL16251 | — | — | 1 | 5.75 |
| CHEMBL280226 | — | — | 1 | 5.75 |
| CHEMBL16127 | — | — | 1 | 5.57 |
| CHEMBL16272 | — | — | 1 | 5.50 |
| CHEMBL49008 | — | — | 1 | 5.33 |
| CHEMBL15781 | — | — | 1 | 5.29 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.24 |
| CHEMBL278246 | — | — | 1 | 4.92 |
| CHEMBL16855 | — | — | 1 | 4.75 |
| CHEMBL16434 | — | — | 1 | 4.68 |
| CHEMBL277515 | — | — | 1 | 4.58 |
| CHEMBL48568 | — | — | 1 | 4.47 |
| CHEMBL16048 | — | — | 1 | 4.26 |
| CHEMBL280471 | — | — | 1 | 4.10 |
| CHEMBL15904 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7162 | NS-398 | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL15945 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL274990 | SC-58125 | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL276506 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL295739 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL277721 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL15791 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL16251 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL280226 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL16127 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL16272 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL49008 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL15781 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL278246 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL16855 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL16434 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL277515 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL48568 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL16048 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL280471 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL15904 | — | IC50 | = | 81000.0 | nM | 4.09 |