Assay Detail
Binding
CHEMBL655661
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Inhibitory concentration against CD45 protein-tyrosine phosphatase using lck-10mer as substrate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Receptor-type tyrosine-protein phosphatase C (CHEMBL3243) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent reversible inhibitors of the protein tyrosine phosphatase CD45.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.44 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300241 | — | — | 1 | 5.72 |
| CHEMBL417727 | — | — | 1 | 5.64 |
| CHEMBL49236 | — | — | 1 | 5.54 |
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | — | 1 | 5.51 |
| CHEMBL51781 | — | — | 1 | 5.50 |
| CHEMBL50347 | — | — | 1 | 5.43 |
| CHEMBL51579 | — | — | 1 | 5.33 |
| CHEMBL49992 | — | — | 1 | 5.31 |
| CHEMBL51880 | — | — | 1 | 4.98 |
| CHEMBL52047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300241 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL417727 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL49236 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL51931 | 9,10-PHENANTHRENEQUINONE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL51781 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL50347 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL51579 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL49992 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL51880 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL52047 | — | IC50 | > | 30000.0 | nM | - |