Assay Detail
Functional
CHEMBL655688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against C-C chemokine receptor type 2
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 34 | 5.96 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432713 | — | — | 1 | 7.30 |
| CHEMBL298562 | — | — | 1 | 7.10 |
| CHEMBL300455 | — | — | 1 | 6.63 |
| CHEMBL297033 | — | — | 1 | 6.46 |
| CHEMBL54192 | — | — | 1 | 6.44 |
| CHEMBL51332 | — | — | 1 | 6.44 |
| CHEMBL299153 | — | — | 1 | 6.38 |
| CHEMBL299322 | — | — | 1 | 6.34 |
| CHEMBL299855 | — | — | 1 | 6.28 |
| CHEMBL50025 | — | — | 1 | 6.26 |
| CHEMBL53476 | — | — | 1 | 6.25 |
| CHEMBL51895 | — | — | 1 | 6.23 |
| CHEMBL51094 | — | — | 1 | 6.18 |
| CHEMBL50460 | — | — | 1 | 6.10 |
| CHEMBL53991 | — | — | 1 | 6.10 |
| CHEMBL53402 | — | — | 1 | 6.06 |
| CHEMBL49994 | — | — | 1 | 5.92 |
| CHEMBL53131 | — | — | 1 | 5.84 |
| CHEMBL300025 | — | — | 1 | 5.80 |
| CHEMBL53130 | — | — | 1 | 5.77 |
| CHEMBL297950 | — | — | 1 | 5.60 |
| CHEMBL53557 | — | — | 1 | 5.55 |
| CHEMBL299379 | — | — | 1 | 5.54 |
| CHEMBL416833 | — | — | 1 | 5.38 |
| CHEMBL53930 | — | — | 1 | 5.36 |
| CHEMBL53779 | — | — | 1 | 5.36 |
| CHEMBL433081 | — | — | 1 | 5.29 |
| CHEMBL53819 | — | — | 1 | 5.27 |
| CHEMBL300744 | — | — | 1 | 5.23 |
| CHEMBL50301 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432713 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL298562 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL300455 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL297033 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL54192 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL51332 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL299153 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL299322 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL299855 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL50025 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL53476 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL51895 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL51094 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL50460 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL53991 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL53402 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL49994 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL53131 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL300025 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL53130 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL297950 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL53557 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL299379 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL416833 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL53930 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL53779 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL433081 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL53819 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL300744 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL50301 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL52956 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL52435 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL53727 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL300868 | — | Ki | > | 10000.0 | nM | - |