Assay Detail
Binding
CHEMBL655691
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Binding displacement of [125I]MCP-1 (0.14 nM) was measured on CHO cell membranes expressing human CCR2 (C-C chemokine receptor type 2)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.29 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41275 | — | — | 1 | 8.38 |
| CHEMBL131243 | — | — | 1 | 7.54 |
| CHEMBL432713 | — | — | 1 | 7.30 |
| CHEMBL134074 | — | — | 1 | 6.68 |
| CHEMBL337246 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41275 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL131243 | — | Ki | = | 28.84 | nM | 7.54 |
| CHEMBL432713 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL134074 | — | Ki | = | 208.93 | nM | 6.68 |
| CHEMBL337246 | — | Ki | = | 288.4 | nM | 6.54 |