Assay Detail
Binding
CHEMBL655698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]MCP-1 binding to the cloned C-C chemokine receptor type 2B expressed in CHO cells
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.88 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432713 | — | — | 1 | 7.30 |
| CHEMBL400698 | — | — | 2 | 7.10 |
| CHEMBL305470 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432713 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL400698 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL400698 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL305470 | — | Ki | = | 630.0 | nM | 6.20 |