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Assay Detail

CHEMBL655779

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Binding
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate
ChEMBL ↗
100
Total Activities
100
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Receptor-type tyrosine-protein phosphatase C (CHEMBL3243) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent reversible inhibitors of the protein tyrosine phosphatase CD45.
Urbanek RA, Suchard SJ, Steelman GB, Knappenberger KS, Sygowski LA, Veale CA, Chapdelaine MJ.
J Med Chem (2001) 44 : 1777 -1793
PubMed 11356112 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 100 5.90 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51314 — — 1 6.70
CHEMBL51579 — — 1 6.40
CHEMBL51781 — — 1 6.40
CHEMBL417727 — — 1 6.40
CHEMBL52491 — — 1 6.40
CHEMBL50149 — — 1 6.30
CHEMBL51776 — — 1 6.30
CHEMBL301801 — — 1 6.30
CHEMBL50973 — — 1 6.30
CHEMBL50347 — — 1 6.30
CHEMBL53966 — — 1 6.30
CHEMBL2372865 — — 1 6.22
CHEMBL49992 — — 1 6.22
CHEMBL50878 — — 1 6.22
CHEMBL2372867 — — 1 6.22
CHEMBL2372871 — — 1 6.22
CHEMBL2372849 — — 1 6.22
CHEMBL54131 — — 1 6.22
CHEMBL51257 — — 1 6.16
CHEMBL2372858 — — 1 6.16
CHEMBL298384 — — 1 6.16
CHEMBL2372854 — — 1 6.16
CHEMBL51931 9,10-PHENANTHRENEQUINONE — 1 6.16
CHEMBL2372878 — — 1 6.16
CHEMBL2372885 — — 1 6.16
CHEMBL2372864 — — 1 6.16
CHEMBL2372889 — — 1 6.16
CHEMBL2372874 — — 1 6.16
CHEMBL2372872 — — 1 6.10
CHEMBL300241 — — 1 6.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51314 — IC50 = 200.0 nM 6.70
CHEMBL51579 — IC50 = 400.0 nM 6.40
CHEMBL51781 — IC50 = 400.0 nM 6.40
CHEMBL417727 — IC50 = 400.0 nM 6.40
CHEMBL52491 — IC50 = 400.0 nM 6.40
CHEMBL50149 — IC50 = 500.0 nM 6.30
CHEMBL51776 — IC50 = 500.0 nM 6.30
CHEMBL301801 — IC50 = 500.0 nM 6.30
CHEMBL50973 — IC50 = 500.0 nM 6.30
CHEMBL50347 — IC50 = 500.0 nM 6.30
CHEMBL53966 — IC50 = 500.0 nM 6.30
CHEMBL54131 — IC50 = 600.0 nM 6.22
CHEMBL49992 — IC50 = 600.0 nM 6.22
CHEMBL50878 — IC50 = 600.0 nM 6.22
CHEMBL2372865 — IC50 = 600.0 nM 6.22
CHEMBL2372867 — IC50 = 600.0 nM 6.22
CHEMBL2372871 — IC50 = 600.0 nM 6.22
CHEMBL2372849 — IC50 = 600.0 nM 6.22
CHEMBL2372874 — IC50 = 700.0 nM 6.16
CHEMBL2372889 — IC50 = 700.0 nM 6.16
CHEMBL2372864 — IC50 = 700.0 nM 6.16
CHEMBL2372885 — IC50 = 700.0 nM 6.16
CHEMBL2372878 — IC50 = 700.0 nM 6.16
CHEMBL2372854 — IC50 = 700.0 nM 6.16
CHEMBL298384 — IC50 = 700.0 nM 6.16
CHEMBL2372858 — IC50 = 700.0 nM 6.16
CHEMBL51257 — IC50 = 700.0 nM 6.16
CHEMBL51931 9,10-PHENANTHRENEQUINONE IC50 = 700.0 nM 6.16
CHEMBL2372872 — IC50 = 800.0 nM 6.10
CHEMBL300241 — IC50 = 800.0 nM 6.10
CHEMBL50846 — IC50 = 800.0 nM 6.10
CHEMBL50161 — IC50 = 800.0 nM 6.10
CHEMBL2372868 — IC50 = 800.0 nM 6.10
CHEMBL300664 — IC50 = 800.0 nM 6.10
CHEMBL49236 — IC50 = 800.0 nM 6.10
CHEMBL51583 — IC50 = 800.0 nM 6.10
CHEMBL2372883 — IC50 = 900.0 nM 6.05
CHEMBL2372881 — IC50 = 900.0 nM 6.05
CHEMBL2372866 — IC50 = 900.0 nM 6.05
CHEMBL3144419 — IC50 = 900.0 nM 6.05
CHEMBL2372893 — IC50 = 900.0 nM 6.05
CHEMBL2372848 — IC50 = 900.0 nM 6.05
CHEMBL301179 — IC50 = 1000.0 nM 6.00
CHEMBL51948 — IC50 = 1000.0 nM 6.00
CHEMBL2372880 — IC50 = 1000.0 nM 6.00
CHEMBL417021 — IC50 = 1000.0 nM 6.00
CHEMBL2372870 — IC50 = 1000.0 nM 6.00
CHEMBL51039 — IC50 = 1000.0 nM 6.00
CHEMBL54154 — IC50 = 1000.0 nM 6.00
CHEMBL50627 — IC50 = 1000.0 nM 6.00