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Assay Detail

CHEMBL655812

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Binding
Inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Low affinity immunoglobulin epsilon Fc receptor (CHEMBL2940)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective inhibition of low affinity IgE receptor (CD23) processing.
Bailey S, Bolognese B, Buckle DR, Faller A, Jackson S, Louis-Flamberg P, McCord M, Mayer RJ, Marshall LA, Smith DG.
Bioorg Med Chem Lett (1998) 8 : 29 -34
PubMed 9871623 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.83 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL115348 1 7.92
CHEMBL118054 1 7.89
CHEMBL324564 1 7.80
CHEMBL115326 1 7.70
CHEMBL424251 1 7.52
CHEMBL326148 1 7.22
CHEMBL116506 1 7.10
CHEMBL116435 1 7.00
CHEMBL320798 1 7.00
CHEMBL279786 BATIMASTAT 2.0 1 7.00
CHEMBL326814 1 6.89
CHEMBL114332 1 6.89
CHEMBL324723 1 6.89
CHEMBL113764 1 6.80
CHEMBL325608 1 6.68
CHEMBL433197 1 6.42
CHEMBL96654 1 5.72
CHEMBL326985 1 5.52
CHEMBL112228 1 5.43
CHEMBL94155 1 5.30
CHEMBL324295 1 -
CHEMBL117823 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL115348 IC50 = 12.0 nM 7.92
CHEMBL118054 IC50 = 13.0 nM 7.89
CHEMBL324564 IC50 = 16.0 nM 7.80
CHEMBL115326 IC50 = 20.0 nM 7.70
CHEMBL424251 IC50 = 30.0 nM 7.52
CHEMBL326148 IC50 = 60.0 nM 7.22
CHEMBL116506 IC50 = 80.0 nM 7.10
CHEMBL116435 IC50 = 100.0 nM 7.00
CHEMBL320798 IC50 = 100.0 nM 7.00
CHEMBL279786 BATIMASTAT IC50 = 100.0 nM 7.00
CHEMBL326814 IC50 = 130.0 nM 6.89
CHEMBL114332 IC50 = 130.0 nM 6.89
CHEMBL324723 IC50 = 130.0 nM 6.89
CHEMBL113764 IC50 = 160.0 nM 6.80
CHEMBL325608 IC50 = 210.0 nM 6.68
CHEMBL433197 IC50 = 380.0 nM 6.42
CHEMBL96654 IC50 = 1900.0 nM 5.72
CHEMBL326985 IC50 = 3000.0 nM 5.52
CHEMBL112228 IC50 = 3700.0 nM 5.43
CHEMBL94155 IC50 = 5000.0 nM 5.30
CHEMBL324295 IC50 ~ 100.0 nM -
CHEMBL117823 IC50 ~ 1000.0 nM -