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Assay Detail

CHEMBL655913

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against Butyrylcholinesterase of horse serum; value ranges from 0.85-1.96
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Butyrylcholinesterase (CHEMBL5077)
Type SINGLE PROTEIN
Organism Equus caballus

Publication

Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
Sterling J, Herzig Y, Goren T, Finkelstein N, Lerner D, Goldenberg W, Miskolczi I, Molnar S, Rantal F, Tamas T, Toth G, Zagyva A, Zekany A, Finberg J, Lavian G, Gross A, Friedman R, Razin M, Huang W, Krais B, Chorev M, Youdim MB, Weinstock M.
J Med Chem (2002) 45 : 5260 -5279
PubMed 12431053 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.02 6.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL544637 1 6.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL544637 IC50 = 950.0 nM 6.02