Assay Detail
Binding
CHEMBL655998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung tissue in the presence of 0.1 uM metoprolol
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Beta-2 adrenergic receptor (CHEMBL2289) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.01 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349978 | — | — | 1 | 6.20 |
| CHEMBL162182 | — | — | 1 | 6.00 |
| CHEMBL162513 | — | — | 1 | 5.47 |
| CHEMBL163587 | — | — | 1 | 5.46 |
| CHEMBL350432 | — | — | 1 | 5.42 |
| CHEMBL350847 | — | — | 1 | 5.37 |
| CHEMBL162200 | — | — | 1 | 5.37 |
| CHEMBL350581 | — | — | 1 | 5.35 |
| CHEMBL163153 | — | — | 1 | 5.34 |
| CHEMBL471 | SOTALOL | 4.0 | 1 | 5.30 |
| CHEMBL165901 | — | — | 1 | 5.21 |
| CHEMBL9841 | — | — | 1 | 4.80 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | 4.75 |
| CHEMBL59597 | — | — | 1 | 4.54 |
| CHEMBL9746 | — | — | 1 | 4.54 |
| CHEMBL162095 | — | — | 1 | 4.51 |
| CHEMBL9666 | — | — | 1 | 4.47 |
| CHEMBL165175 | — | — | 1 | 4.40 |
| CHEMBL351183 | — | — | 1 | 4.38 |
| CHEMBL165012 | — | — | 1 | 4.25 |
| CHEMBL114478 | — | — | 1 | 4.16 |
| CHEMBL165462 | — | — | 1 | - |
| CHEMBL166330 | — | — | 1 | - |
| CHEMBL163363 | — | — | 1 | - |
| CHEMBL59517 | — | — | 1 | - |
| CHEMBL9434 | PHENYLPIPERAZINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349978 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL162182 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL162513 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL163587 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL350432 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL350847 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL162200 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL350581 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL163153 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL471 | SOTALOL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL165901 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL9841 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL59597 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL9746 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL162095 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL9666 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL165175 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL351183 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL165012 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL114478 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL165462 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL166330 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL163363 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL59517 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL9434 | PHENYLPIPERAZINE | IC50 | > | 100000.0 | nM | - |