Assay Detail
Binding
CHEMBL656194
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Inhibitory activity using recombinant human Calpain 1 with Suc-Leu-Tyr-MNA as substrate.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nonpeptidic inhibitors of recombinant human calpain I
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.30 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423112 | — | — | 1 | 7.96 |
| CHEMBL42716 | — | — | 1 | 7.60 |
| CHEMBL98832 | — | — | 1 | 7.52 |
| CHEMBL100316 | — | — | 1 | 7.30 |
| CHEMBL439590 | — | — | 1 | 7.12 |
| CHEMBL316721 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423112 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL42716 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL98832 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL100316 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL439590 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL316721 | — | IC50 | = | 500.0 | nM | 6.30 |