Assay Detail
Binding
CHEMBL656196
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Inhibitory activity towards human calpain I
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.84 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117553 | — | — | 1 | 7.82 |
| CHEMBL118688 | — | — | 1 | 7.68 |
| CHEMBL269384 | — | — | 1 | 7.48 |
| CHEMBL333622 | — | — | 1 | 6.97 |
| CHEMBL420698 | — | — | 1 | 6.96 |
| CHEMBL117729 | — | — | 1 | 6.70 |
| CHEMBL332683 | — | — | 1 | 6.70 |
| CHEMBL115572 | — | — | 1 | 6.52 |
| CHEMBL117006 | — | — | 1 | 6.30 |
| CHEMBL323656 | — | — | 1 | 6.10 |
| CHEMBL332638 | — | — | 1 | 6.00 |
| CHEMBL326758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117553 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL118688 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL269384 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL333622 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL420698 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL117729 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL332683 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL115572 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL117006 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL323656 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL332638 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL326758 | — | IC50 | ~ | 1000.0 | nM | - |