Assay Detail
Binding
CHEMBL656202
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Inhibitory activity against human Calpain 1 isolated from erythrocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.47 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310855 | — | — | 1 | 8.08 |
| CHEMBL77784 | — | — | 1 | 7.88 |
| CHEMBL80903 | — | — | 1 | 7.82 |
| CHEMBL423112 | — | — | 1 | 7.81 |
| CHEMBL80933 | — | — | 1 | 7.74 |
| CHEMBL80605 | — | — | 1 | 7.57 |
| CHEMBL26631 | — | — | 1 | 6.85 |
| CHEMBL281874 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310855 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL77784 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL80903 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL423112 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL80933 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL80605 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL26631 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL281874 | — | Ki | = | 1080.0 | nM | 5.97 |