Assay Detail
Binding
CHEMBL656249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Minor structural differences in Boc-CCK-4 derivatives dictate affinity and selectivity for CCK-A and CCK-B receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.19 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142898 | — | — | 1 | 7.92 |
| CHEMBL3143025 | — | — | 1 | 7.51 |
| CHEMBL3142904 | — | — | 1 | 6.82 |
| CHEMBL3142924 | — | — | 1 | 6.12 |
| CHEMBL3142903 | — | — | 1 | 6.09 |
| CHEMBL3142905 | — | — | 1 | 6.00 |
| CHEMBL3142899 | — | — | 1 | 5.96 |
| CHEMBL3142912 | — | — | 1 | 5.92 |
| CHEMBL262767 | — | — | 1 | 5.92 |
| CHEMBL320868 | — | — | 1 | 5.85 |
| CHEMBL3142923 | — | — | 1 | 5.85 |
| CHEMBL98468 | — | — | 1 | 5.72 |
| CHEMBL3142906 | — | — | 1 | 5.51 |
| CHEMBL100609 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142898 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3143025 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3142904 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3142924 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3142903 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3142905 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3142899 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3142912 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL262767 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL320868 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3142923 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL98468 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3142906 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL100609 | — | IC50 | = | 3400.0 | nM | 5.47 |