Assay Detail
Binding
CHEMBL656311
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Inhibition of phosphodiesterase 4 from guinea pig lung
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.69 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156140 | — | — | 1 | 6.89 |
| CHEMBL351568 | — | — | 1 | 6.64 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.23 |
| CHEMBL345917 | — | — | 1 | 6.05 |
| CHEMBL351567 | — | — | 1 | 5.82 |
| CHEMBL445643 | — | — | 1 | 5.42 |
| CHEMBL88990 | NITRAQUAZONE | 2.0 | 1 | 4.94 |
| CHEMBL155681 | — | — | 1 | 4.67 |
| CHEMBL156139 | — | — | 1 | 4.59 |
| CHEMBL157181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156140 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL351568 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL345917 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL351567 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL445643 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL88990 | NITRAQUAZONE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL155681 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL156139 | — | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL157181 | — | IC50 | > | 100000.0 | nM | - |