Assay Detail
Binding
CHEMBL656313
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Inhibition of phosphodiesterase 4 from rat brain cortex
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.77 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156140 | — | — | 1 | 7.40 |
| CHEMBL351567 | — | — | 1 | 7.16 |
| CHEMBL345917 | — | — | 1 | 7.00 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.31 |
| CHEMBL351568 | — | — | 1 | 6.00 |
| CHEMBL157181 | — | — | 1 | - |
| CHEMBL156328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156140 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL351567 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL345917 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL351568 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL157181 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL156328 | — | IC50 | > | 10000.0 | nM | - |