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Assay Detail

CHEMBL656544

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of growth of human carcinoma CX-1 cell line (clonogenic assay).
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CX-1
Confidence 1 — Organism
Curated By Expert

Target

CX-1 (CHEMBL614566)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-activity of novel rhodacyanine dyes as antitumor agents.
Kawakami M, Koya K, Ukai T, Tatsuta N, Ikegawa A, Ogawa K, Shishido T, Chen LB.
J Med Chem (1998) 41 : 130 -142
PubMed 9438030 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 6.80 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL283925 1 8.00
CHEMBL418210 1 7.70
CHEMBL281061 1 7.52
CHEMBL30750 1 7.52
CHEMBL286127 1 7.40
CHEMBL286906 1 7.40
CHEMBL30685 1 7.30
CHEMBL280643 1 7.22
CHEMBL284509 1 7.22
CHEMBL411107 1 7.10
CHEMBL33149 1 6.96
CHEMBL439918 1 6.80
CHEMBL34571 1 6.80
CHEMBL31074 1 6.75
CHEMBL413815 1 6.64
CHEMBL34783 1 6.55
CHEMBL287420 1 6.41
CHEMBL34336 1 6.17
CHEMBL285178 1 6.10
CHEMBL33859 1 6.09
CHEMBL33502 1 5.98
CHEMBL30428 1 5.96
CHEMBL33122 1 5.77
CHEMBL432458 1 5.75
CHEMBL367278 1 -
CHEMBL34157 1 -
CHEMBL431879 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL283925 IC50 = 10.0 nM 8.00
CHEMBL418210 IC50 = 20.0 nM 7.70
CHEMBL281061 IC50 = 30.0 nM 7.52
CHEMBL30750 IC50 = 30.0 nM 7.52
CHEMBL286127 IC50 = 40.0 nM 7.40
CHEMBL286906 IC50 = 40.0 nM 7.40
CHEMBL30685 IC50 = 50.0 nM 7.30
CHEMBL280643 IC50 = 60.0 nM 7.22
CHEMBL284509 IC50 = 60.0 nM 7.22
CHEMBL411107 IC50 = 80.0 nM 7.10
CHEMBL33149 IC50 = 110.0 nM 6.96
CHEMBL439918 IC50 = 160.0 nM 6.80
CHEMBL34571 IC50 = 160.0 nM 6.80
CHEMBL31074 IC50 = 180.0 nM 6.75
CHEMBL413815 IC50 = 230.0 nM 6.64
CHEMBL34783 IC50 = 280.0 nM 6.55
CHEMBL287420 IC50 = 390.0 nM 6.41
CHEMBL34336 IC50 = 680.0 nM 6.17
CHEMBL285178 IC50 = 800.0 nM 6.10
CHEMBL33859 IC50 = 810.0 nM 6.09
CHEMBL33502 IC50 = 1040.0 nM 5.98
CHEMBL30428 IC50 = 1100.0 nM 5.96
CHEMBL33122 IC50 = 1710.0 nM 5.77
CHEMBL432458 IC50 = 1760.0 nM 5.75
CHEMBL367278 IC50 > 1500.0 nM -
CHEMBL34157 IC50 > 2400.0 nM -
CHEMBL431879 IC50 > 1800.0 nM -