Assay Detail
Binding
CHEMBL656566
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50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree C
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.00 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788291 | — | — | 1 | 8.44 |
| CHEMBL417975 | SEZOLAMIDE | 2.0 | 1 | 8.40 |
| CHEMBL2092886 | — | — | 1 | 8.34 |
| CHEMBL314569 | — | — | 1 | 8.28 |
| CHEMBL1204135 | SEZOLAMIDE HYDROCHLORIDE | -1.0 | 1 | 8.23 |
| CHEMBL1788205 | — | — | 1 | 8.17 |
| CHEMBL545239 | — | — | 1 | 8.14 |
| CHEMBL543604 | — | — | 1 | 8.04 |
| CHEMBL554091 | — | — | 1 | 8.04 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL554854 | — | — | 1 | 7.91 |
| CHEMBL545245 | — | — | 1 | 7.86 |
| CHEMBL2092885 | — | — | 1 | 7.69 |
| CHEMBL2092887 | — | — | 1 | 7.28 |
| CHEMBL555182 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788291 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL417975 | SEZOLAMIDE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2092886 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL314569 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1204135 | SEZOLAMIDE HYDROCHLORIDE | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1788205 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL545239 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL543604 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL554091 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL554854 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL545245 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL2092885 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL2092887 | — | IC50 | = | 53.1 | nM | 7.28 |
| CHEMBL555182 | — | IC50 | = | 70.0 | nM | 7.16 |