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Assay Detail

CHEMBL656568

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Binding
Inhibition of human erythrocyte carbonic anhydrase II
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors.
Hartman GD, Halczenko W, Prugh JD, Smith RL, Sugrue MF, Mallorga P, Michelson SR, Randall WC, Schwam H, Sondey JM.
J Med Chem (1992) 35 : 3027 -3033
PubMed 1501230 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 8.06 8.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL103143 1 8.29
CHEMBL105080 1 8.25
CHEMBL105713 1 8.22
CHEMBL103255 1 8.19
CHEMBL103271 1 8.10
CHEMBL322014 1 8.10
CHEMBL101371 1 8.09
CHEMBL103087 1 8.05
CHEMBL103621 1 7.96
CHEMBL317694 1 7.96
CHEMBL316757 1 7.96
CHEMBL106493 1 7.92
CHEMBL101370 1 7.92
CHEMBL101792 1 7.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL103143 IC50 = 5.1 nM 8.29
CHEMBL105080 IC50 = 5.6 nM 8.25
CHEMBL105713 IC50 = 6.0 nM 8.22
CHEMBL103255 IC50 = 6.49 nM 8.19
CHEMBL103271 IC50 = 8.0 nM 8.10
CHEMBL322014 IC50 = 8.0 nM 8.10
CHEMBL101371 IC50 = 8.2 nM 8.09
CHEMBL103087 IC50 = 9.0 nM 8.05
CHEMBL103621 IC50 = 11.0 nM 7.96
CHEMBL317694 IC50 = 11.0 nM 7.96
CHEMBL316757 IC50 = 11.0 nM 7.96
CHEMBL106493 IC50 = 12.0 nM 7.92
CHEMBL101370 IC50 = 12.0 nM 7.92
CHEMBL101792 IC50 = 14.0 nM 7.85