Assay Detail
Binding
CHEMBL656574
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In vitro inhibition of human Carbonic Anhydrase II
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.40 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84151 | — | — | 1 | 8.92 |
| CHEMBL84600 | — | — | 1 | 8.92 |
| CHEMBL84649 | — | — | 1 | 8.92 |
| CHEMBL309608 | — | — | 1 | 8.85 |
| CHEMBL311904 | — | — | 1 | 8.80 |
| CHEMBL310848 | — | — | 1 | 8.74 |
| CHEMBL311548 | — | — | 1 | 8.74 |
| CHEMBL81688 | — | — | 1 | 8.70 |
| CHEMBL79951 | — | — | 1 | 8.66 |
| CHEMBL86282 | — | — | 1 | 8.55 |
| CHEMBL84224 | — | — | 1 | 8.54 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL311810 | — | — | 1 | 8.49 |
| CHEMBL312635 | — | — | 1 | 8.49 |
| CHEMBL85558 | — | — | 1 | 8.46 |
| CHEMBL442751 | — | — | 1 | 8.40 |
| CHEMBL82230 | — | — | 1 | 8.40 |
| CHEMBL82510 | — | — | 1 | 8.40 |
| CHEMBL312593 | — | — | 1 | 8.40 |
| CHEMBL6685 | — | — | 1 | 8.40 |
| CHEMBL84021 | — | — | 1 | 8.39 |
| CHEMBL79738 | — | — | 1 | 8.30 |
| CHEMBL312813 | — | — | 1 | 8.22 |
| CHEMBL80028 | — | — | 1 | 8.17 |
| CHEMBL82557 | — | — | 1 | 8.17 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.00 |
| CHEMBL310291 | — | — | 1 | 8.00 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.68 |
| CHEMBL79472 | — | — | 1 | 7.50 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84151 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL84600 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL84649 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL309608 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL311904 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL310848 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL311548 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL81688 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL79951 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL86282 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL84224 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL18 | ETHOXZOLAMIDE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL311810 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL312635 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL85558 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL442751 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL82230 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL82510 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL312593 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL6685 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL84021 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL79738 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL312813 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL80028 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL82557 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL310291 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL19 | METHAZOLAMIDE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL79472 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL17 | DICHLORPHENAMIDE | IC50 | = | 40.0 | nM | 7.40 |