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Assay Detail

CHEMBL656581

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Binding
Activity against human carbonic anhydrase II
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2-thiophenesulfonamides.
Holmes JM, Lee GC, Wijono M, Weinkam R, Wheeler LA, Garst ME.
J Med Chem (1994) 37 : 1646 -1651
PubMed 8201598 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.73 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL42278 1 8.70
CHEMBL417975 SEZOLAMIDE 2.0 1 8.40
CHEMBL42675 1 8.33
CHEMBL44173 1 8.30
CHEMBL42425 1 8.24
CHEMBL20 ACETAZOLAMIDE 4.0 1 8.22
CHEMBL297821 1 8.20
CHEMBL43440 1 8.17
CHEMBL44335 1 7.89
CHEMBL288606 1 7.82
CHEMBL287738 1 7.80
CHEMBL43047 1 6.80
CHEMBL289952 1 6.70
CHEMBL44238 1 6.23
CHEMBL42080 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL42278 IC50 = 2.0 nM 8.70
CHEMBL417975 SEZOLAMIDE IC50 = 4.0 nM 8.40
CHEMBL42675 IC50 = 4.7 nM 8.33
CHEMBL44173 IC50 = 5.0 nM 8.30
CHEMBL42425 IC50 = 5.8 nM 8.24
CHEMBL20 ACETAZOLAMIDE IC50 = 6.0 nM 8.22
CHEMBL297821 IC50 = 6.3 nM 8.20
CHEMBL43440 IC50 = 6.8 nM 8.17
CHEMBL44335 IC50 = 13.0 nM 7.89
CHEMBL288606 IC50 = 15.0 nM 7.82
CHEMBL287738 IC50 = 16.0 nM 7.80
CHEMBL43047 IC50 = 160.0 nM 6.80
CHEMBL289952 IC50 = 200.0 nM 6.70
CHEMBL44238 IC50 = 590.0 nM 6.23
CHEMBL42080 IC50 = 626.0 nM 6.20