Assay Detail
Binding
CHEMBL656649
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In vitro inhibitory activity against Catechol-O-methyltransferase from porcine liver; Uncompetitive mode of inhibition
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and in vitro evaluation of two progressive series of bifunctional polyhydroxybenzamide catechol-O-methyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.74 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302625 | — | — | 1 | 5.18 |
| CHEMBL264858 | — | — | 1 | 4.57 |
| CHEMBL60350 | — | — | 1 | 4.46 |
| CHEMBL292067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302625 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL264858 | — | Ki | = | 26700.0 | nM | 4.57 |
| CHEMBL60350 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL292067 | — | Ki | = | 136000.0 | nM | - |