Assay Detail
Functional
CHEMBL656824
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Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COR-L23 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.36 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162781 | — | — | 1 | 7.92 |
| CHEMBL165982 | — | — | 1 | 7.77 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.70 |
| CHEMBL162451 | — | — | 1 | 7.70 |
| CHEMBL422019 | — | — | 1 | 7.62 |
| CHEMBL350316 | — | — | 1 | 7.37 |
| CHEMBL163399 | — | — | 1 | 7.10 |
| CHEMBL350096 | — | — | 1 | 7.02 |
| CHEMBL162112 | — | — | 1 | 6.85 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162781 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL165982 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL162451 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL422019 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL350316 | — | IC50 | = | 42.9 | nM | 7.37 |
| CHEMBL163399 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL350096 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL162112 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 319.3 | nM | 6.50 |