Assay Detail
Binding
CHEMBL656925
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Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.52 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.22 |
| CHEMBL2371222 | — | — | 1 | 7.75 |
| CHEMBL2371221 | — | — | 1 | 7.64 |
| CHEMBL3143501 | — | — | 1 | 7.10 |
| CHEMBL333477 | — | — | 1 | 7.06 |
| CHEMBL120632 | TETRAGASTRIN | -1.0 | 1 | 7.03 |
| CHEMBL2371225 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2371222 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2371221 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3143501 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL333477 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL120632 | TETRAGASTRIN | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL2371225 | — | Ki | = | 142.0 | nM | 6.85 |