Assay Detail
Binding
CHEMBL656926
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Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of potent, selective, hexapeptide CCK-A agonist anorectic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.08 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.39 |
| CHEMBL137280 | — | — | 1 | 8.89 |
| CHEMBL136096 | — | — | 1 | 7.08 |
| CHEMBL341762 | — | — | 1 | 6.82 |
| CHEMBL1161142 | — | — | 1 | 6.65 |
| CHEMBL345049 | — | — | 1 | 6.37 |
| CHEMBL423907 | — | — | 1 | 5.80 |
| CHEMBL1791002 | — | — | 1 | 5.66 |
| CHEMBL1791005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL137280 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL136096 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL341762 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1161142 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL345049 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL423907 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL1791002 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1791005 | — | Ki | > | 1000.0 | nM | - |