Assay Detail
Functional
CHEMBL657022
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In vitro antifungal activity against Candida albicans (CY1002) in 80% calf serum
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Candida albicans |
| Tissue | Serum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.91 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170807 | — | — | 1 | 7.09 |
| CHEMBL170524 | — | — | 1 | 6.72 |
| CHEMBL171506 | — | — | 1 | 6.38 |
| CHEMBL355250 | — | — | 1 | 6.33 |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 6.30 |
| CHEMBL422746 | — | — | 1 | 6.13 |
| CHEMBL173370 | — | — | 1 | 5.92 |
| CHEMBL422896 | — | — | 1 | 5.57 |
| CHEMBL355497 | — | — | 1 | 5.52 |
| CHEMBL353541 | — | — | 1 | 5.29 |
| CHEMBL173962 | — | — | 1 | 5.08 |
| CHEMBL368134 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170807 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL170524 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL171506 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL355250 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL422746 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL173370 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL422896 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL355497 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL353541 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL173962 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL368134 | — | IC50 | = | 25000.0 | nM | 4.60 |