Assay Detail
Functional
CHEMBL657023
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In vitro antifungal activity against Candida albicans (CY1002) in YNBPB medium
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Candida albicans |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.83 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422896 | — | — | 1 | 7.72 |
| CHEMBL173370 | — | — | 1 | 7.46 |
| CHEMBL170524 | — | — | 1 | 7.41 |
| CHEMBL171506 | — | — | 1 | 7.32 |
| CHEMBL355250 | — | — | 1 | 7.19 |
| CHEMBL355497 | — | — | 1 | 6.92 |
| CHEMBL422746 | — | — | 1 | 6.85 |
| CHEMBL353541 | — | — | 1 | 6.47 |
| CHEMBL173962 | — | — | 1 | 6.27 |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | 6.14 |
| CHEMBL368134 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422896 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL173370 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL170524 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL171506 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL355250 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL355497 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL422746 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL353541 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL173962 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL106 | FLUCONAZOLE | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL368134 | — | IC50 | = | 4600.0 | nM | 5.34 |