Assay Detail
Binding
CHEMBL657056
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Binding affinity for the cannabinoid receptor in the presence of phenylmethanesulfonyl fluoride (PMSF) was determined in rat fore brain membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
(R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.21 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120526 | METHANANDAMIDE | — | 1 | 7.70 |
| CHEMBL330974 | — | — | 1 | 7.58 |
| CHEMBL15848 | ANANDAMIDE | — | 1 | 7.11 |
| CHEMBL346659 | — | — | 1 | 6.92 |
| CHEMBL348466 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120526 | METHANANDAMIDE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL330974 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL15848 | ANANDAMIDE | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL346659 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL348466 | — | Ki | = | 173.0 | nM | 6.76 |