Assay Detail
Binding
CHEMBL657146
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Inhibitory activity against human carbonic anhydrase II (CA2)
130
Total Activities
130
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 130 | 7.65 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13630 | — | — | 1 | 9.22 |
| CHEMBL319487 | — | — | 1 | 8.70 |
| CHEMBL268439 | — | — | 1 | 8.70 |
| CHEMBL103630 | — | — | 1 | 8.70 |
| CHEMBL13646 | — | — | 1 | 8.52 |
| CHEMBL317256 | — | — | 1 | 8.52 |
| CHEMBL100906 | — | — | 1 | 8.40 |
| CHEMBL99855 | — | — | 1 | 8.40 |
| CHEMBL97795 | — | — | 1 | 8.40 |
| CHEMBL103015 | — | — | 1 | 8.40 |
| CHEMBL100860 | — | — | 1 | 8.30 |
| CHEMBL421200 | — | — | 1 | 8.30 |
| CHEMBL102722 | — | — | 1 | 8.30 |
| CHEMBL103770 | — | — | 1 | 8.30 |
| CHEMBL103392 | — | — | 1 | 8.30 |
| CHEMBL103420 | — | — | 1 | 8.30 |
| CHEMBL101330 | — | — | 1 | 8.30 |
| CHEMBL318953 | — | — | 1 | 8.22 |
| CHEMBL100733 | — | — | 1 | 8.22 |
| CHEMBL103615 | — | — | 1 | 8.22 |
| CHEMBL269122 | — | — | 1 | 8.22 |
| CHEMBL101190 | — | — | 1 | 8.22 |
| CHEMBL287117 | — | — | 1 | 8.15 |
| CHEMBL100456 | — | — | 1 | 8.15 |
| CHEMBL439957 | — | — | 1 | 8.15 |
| CHEMBL103524 | — | — | 1 | 8.15 |
| CHEMBL319297 | — | — | 1 | 8.15 |
| CHEMBL99736 | — | — | 1 | 8.15 |
| CHEMBL100075 | — | — | 1 | 8.15 |
| CHEMBL320436 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13630 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL319487 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL103630 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL268439 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL317256 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL13646 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL99855 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL97795 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL103015 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL100906 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL102722 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL421200 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL100860 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL103770 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL103392 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL101330 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL103420 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL101190 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL100733 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL318953 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL103615 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL269122 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL439957 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL103524 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL99736 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL100456 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL287117 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL319297 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL100075 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL319486 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL431421 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL6685 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL319897 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL103478 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL320436 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL420105 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL321052 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL102705 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL14182 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL102401 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL35118 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL318839 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL318969 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL319030 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL103825 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL103945 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL103413 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL6633 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL320591 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL319182 | — | Ki | = | 12.0 | nM | 7.92 |