Assay Detail
Binding
CHEMBL657148
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Inhibitory activity against human cloned Carbonic anhydrase II (hCA II, cytosolic form).
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13646 | — | — | 1 | 8.52 |
| CHEMBL90382 | — | — | 1 | 8.52 |
| CHEMBL420610 | — | — | 1 | 8.40 |
| CHEMBL6685 | — | — | 1 | 8.10 |
| CHEMBL88232 | — | — | 1 | 8.10 |
| CHEMBL88519 | — | — | 1 | 8.05 |
| CHEMBL35118 | — | — | 1 | 8.05 |
| CHEMBL432818 | — | — | 1 | 7.92 |
| CHEMBL90218 | — | — | 1 | 7.60 |
| CHEMBL330346 | — | — | 1 | 6.88 |
| CHEMBL86751 | — | — | 1 | 6.60 |
| CHEMBL327669 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13646 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL90382 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL420610 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL6685 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL88232 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL88519 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL35118 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL432818 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL90218 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL330346 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL86751 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL327669 | — | Ki | = | 260.0 | nM | 6.58 |