Assay Detail
Binding
CHEMBL657149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human recombinant carbonic anhydrase II
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 47 | 7.52 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316037 | — | — | 1 | 8.70 |
| CHEMBL313925 | — | — | 1 | 8.70 |
| CHEMBL314929 | — | — | 1 | 8.52 |
| CHEMBL89163 | — | — | 1 | 8.52 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.49 |
| CHEMBL327487 | — | — | 1 | 8.30 |
| CHEMBL313770 | — | — | 1 | 8.30 |
| CHEMBL85079 | — | — | 1 | 8.22 |
| CHEMBL287117 | — | — | 1 | 8.15 |
| CHEMBL85120 | — | — | 1 | 8.15 |
| CHEMBL88860 | — | — | 1 | 8.15 |
| CHEMBL87141 | — | — | 1 | 8.10 |
| CHEMBL328946 | — | — | 1 | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL88173 | — | — | 1 | 8.05 |
| CHEMBL89634 | — | — | 1 | 8.00 |
| CHEMBL88120 | — | — | 1 | 8.00 |
| CHEMBL89945 | — | — | 1 | 7.82 |
| CHEMBL6753 | — | — | 1 | 7.72 |
| CHEMBL280071 | — | — | 1 | 7.70 |
| CHEMBL269628 | — | — | 1 | 7.55 |
| CHEMBL86428 | — | — | 1 | 7.52 |
| CHEMBL316140 | — | — | 1 | 7.51 |
| CHEMBL88969 | — | — | 1 | 7.51 |
| CHEMBL327933 | — | — | 1 | 7.48 |
| CHEMBL315661 | — | — | 1 | 7.44 |
| CHEMBL6724 | — | — | 1 | 7.40 |
| CHEMBL89455 | — | — | 1 | 7.38 |
| CHEMBL315592 | — | — | 1 | 7.36 |
| CHEMBL265674 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316037 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL313925 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL89163 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL314929 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL327487 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL313770 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL85079 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL287117 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL85120 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL88860 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL87141 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL328946 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL88173 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL89634 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL88120 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL89945 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL6753 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL280071 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL269628 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL86428 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL88969 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL316140 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL327933 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL315661 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL6724 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL89455 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL315592 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL265674 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL6853 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL268177 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL266240 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL7092 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL6784 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL90492 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL6919 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL7087 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL419 | MAFENIDE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL6852 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL92116 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL327604 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL91420 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL313123 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL6705 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL7204 | — | Ki | = | 320.0 | nM | 6.50 |