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Assay Detail

CHEMBL657151

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Binding
Inhibitory activity against human isoenzyme Carbonic anhydrase II
ChEMBL ↗
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 2 (CHEMBL205) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Scozzafava A, Supuran CT.
J Med Chem (2000) 43 : 3677 -3687
PubMed 11020282 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 64 7.59 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL122925 — — 1 9.10
CHEMBL333532 — — 1 9.05
CHEMBL332362 — — 1 8.96
CHEMBL331114 — — 1 8.40
CHEMBL98328 — — 1 8.33
CHEMBL121592 — — 1 8.30
CHEMBL123382 — — 1 8.30
CHEMBL121501 — — 1 8.30
CHEMBL331669 — — 1 8.10
CHEMBL123167 — — 1 8.10
CHEMBL121729 — — 1 8.05
CHEMBL122109 — — 1 8.05
CHEMBL332406 — — 1 7.96
CHEMBL120049 — — 1 7.96
CHEMBL120934 — — 1 7.89
CHEMBL332858 — — 1 7.82
CHEMBL332439 — — 1 7.82
CHEMBL333248 — — 1 7.82
CHEMBL332429 — — 1 7.80
CHEMBL123404 — — 1 7.75
CHEMBL123443 — — 1 7.75
CHEMBL332145 — — 1 7.72
CHEMBL301469 — — 1 7.68
CHEMBL55310 — — 1 7.58
CHEMBL123233 — — 1 7.54
CHEMBL331308 — — 1 7.52
CHEMBL83508 — — 1 7.50
CHEMBL333896 — — 1 7.46
CHEMBL262676 — — 1 7.44
CHEMBL123105 — — 1 7.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL122925 — Ki = 0.8 nM 9.10
CHEMBL333532 — Ki = 0.9 nM 9.05
CHEMBL332362 — Ki = 1.1 nM 8.96
CHEMBL331114 — Ki = 4.0 nM 8.40
CHEMBL98328 — Ki = 4.7 nM 8.33
CHEMBL121592 — Ki = 5.0 nM 8.30
CHEMBL123382 — Ki = 5.0 nM 8.30
CHEMBL121501 — Ki = 5.0 nM 8.30
CHEMBL331669 — Ki = 8.0 nM 8.10
CHEMBL123167 — Ki = 8.0 nM 8.10
CHEMBL121729 — Ki = 9.0 nM 8.05
CHEMBL122109 — Ki = 9.0 nM 8.05
CHEMBL332406 — Ki = 11.0 nM 7.96
CHEMBL120049 — Ki = 11.0 nM 7.96
CHEMBL120934 — Ki = 13.0 nM 7.89
CHEMBL332858 — Ki = 15.0 nM 7.82
CHEMBL333248 — Ki = 15.0 nM 7.82
CHEMBL332439 — Ki = 15.0 nM 7.82
CHEMBL332429 — Ki = 16.0 nM 7.80
CHEMBL123404 — Ki = 18.0 nM 7.75
CHEMBL123443 — Ki = 18.0 nM 7.75
CHEMBL332145 — Ki = 19.0 nM 7.72
CHEMBL301469 — Ki = 21.0 nM 7.68
CHEMBL55310 — Ki = 26.0 nM 7.58
CHEMBL123233 — Ki = 29.0 nM 7.54
CHEMBL331308 — Ki = 30.0 nM 7.52
CHEMBL83508 — Ki = 32.0 nM 7.50
CHEMBL333896 — Ki = 35.0 nM 7.46
CHEMBL262676 — Ki = 36.0 nM 7.44
CHEMBL123105 — Ki = 37.0 nM 7.43
CHEMBL123463 — Ki = 38.0 nM 7.42
CHEMBL121916 — Ki = 39.0 nM 7.41
CHEMBL330950 — Ki = 40.0 nM 7.40
CHEMBL122950 — Ki = 44.0 nM 7.36
CHEMBL332755 — Ki = 45.0 nM 7.35
CHEMBL122868 — Ki = 51.0 nM 7.29
CHEMBL340461 — Ki = 56.0 nM 7.25
CHEMBL123064 — Ki = 62.0 nM 7.21
CHEMBL121559 — Ki = 70.0 nM 7.16
CHEMBL122711 — Ki = 74.0 nM 7.13
CHEMBL441084 — Ki = 85.0 nM 7.07
CHEMBL123041 — Ki = 92.0 nM 7.04
CHEMBL122719 — Ki = 100.0 nM 7.00
CHEMBL330857 — Ki = 108.0 nM 6.97
CHEMBL293503 — Ki = 107.0 nM 6.97
CHEMBL331311 — Ki = 116.0 nM 6.94
CHEMBL55110 — Ki = 118.0 nM 6.93
CHEMBL316169 — Ki = 120.0 nM 6.92
CHEMBL82868 — Ki = 120.0 nM 6.92
CHEMBL124237 — Ki = 150.0 nM 6.82