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Assay Detail

CHEMBL657153

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human recombinant carbonic anhydrase II (CA2)
131
Total Activities
131
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
Scozzafava A, Briganti F, Mincione G, Menabuoni L, Mincione F, Supuran CT.
J Med Chem (1999) 42 : 3690 -3700
PubMed 10479300 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 131 7.72 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL331083 1 9.22
CHEMBL419604 1 8.96
CHEMBL331697 1 8.89
CHEMBL122786 1 8.82
CHEMBL123606 1 8.74
CHEMBL268439 1 8.70
CHEMBL2112600 1 8.70
CHEMBL332220 1 8.70
CHEMBL332648 1 8.70
CHEMBL331527 1 8.70
CHEMBL451190 1 8.70
CHEMBL123599 1 8.52
CHEMBL13646 1 8.52
CHEMBL123539 1 8.52
CHEMBL333874 1 8.52
CHEMBL122720 1 8.52
CHEMBL332221 1 8.52
CHEMBL330755 1 8.52
CHEMBL341002 1 8.52
CHEMBL123108 1 8.40
CHEMBL541990 1 8.40
CHEMBL331386 1 8.40
CHEMBL332222 1 8.30
CHEMBL126179 1 8.30
CHEMBL122349 1 8.30
CHEMBL122781 1 8.22
CHEMBL333692 1 8.22
CHEMBL269122 1 8.22
CHEMBL2112602 1 8.22
CHEMBL2112599 1 8.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL331083 Ki = 0.6 nM 9.22
CHEMBL419604 Ki = 1.1 nM 8.96
CHEMBL331697 Ki = 1.3 nM 8.89
CHEMBL122786 Ki = 1.5 nM 8.82
CHEMBL123606 Ki = 1.8 nM 8.74
CHEMBL451190 Ki = 2.0 nM 8.70
CHEMBL268439 Ki = 2.0 nM 8.70
CHEMBL331527 Ki = 2.0 nM 8.70
CHEMBL332648 Ki = 2.0 nM 8.70
CHEMBL332220 Ki = 2.0 nM 8.70
CHEMBL2112600 Ki = 2.0 nM 8.70
CHEMBL330755 Ki = 3.0 nM 8.52
CHEMBL122720 Ki = 3.0 nM 8.52
CHEMBL123599 Ki = 3.0 nM 8.52
CHEMBL332221 Ki = 3.0 nM 8.52
CHEMBL333874 Ki = 3.0 nM 8.52
CHEMBL123539 Ki = 3.0 nM 8.52
CHEMBL13646 Ki = 3.0 nM 8.52
CHEMBL341002 Ki = 3.0 nM 8.52
CHEMBL123108 Ki = 4.0 nM 8.40
CHEMBL331386 Ki = 4.0 nM 8.40
CHEMBL541990 Ki = 4.0 nM 8.40
CHEMBL332222 Ki = 5.0 nM 8.30
CHEMBL122349 Ki = 5.0 nM 8.30
CHEMBL126179 Ki = 5.0 nM 8.30
CHEMBL122781 Ki = 6.0 nM 8.22
CHEMBL269122 Ki = 6.0 nM 8.22
CHEMBL2112602 Ki = 6.0 nM 8.22
CHEMBL2112599 Ki = 6.0 nM 8.22
CHEMBL333692 Ki = 6.0 nM 8.22
CHEMBL122444 Ki = 6.0 nM 8.22
CHEMBL122951 Ki = 6.0 nM 8.22
CHEMBL123065 Ki = 7.0 nM 8.15
CHEMBL123047 Ki = 7.0 nM 8.15
CHEMBL287117 Ki = 7.0 nM 8.15
CHEMBL125338 Ki = 8.0 nM 8.10
CHEMBL6685 Ki = 8.0 nM 8.10
CHEMBL122926 Ki = 8.0 nM 8.10
CHEMBL122390 Ki = 8.0 nM 8.10
CHEMBL123482 Ki = 8.0 nM 8.10
CHEMBL123398 Ki = 8.0 nM 8.10
CHEMBL340503 Ki = 9.0 nM 8.05
CHEMBL218490 DORZOLAMIDE Ki = 9.0 nM 8.05
CHEMBL122756 Ki = 9.0 nM 8.05
CHEMBL122808 Ki = 9.0 nM 8.05
CHEMBL340569 Ki = 9.0 nM 8.05
CHEMBL35118 Ki = 9.0 nM 8.05
CHEMBL121782 Ki = 9.0 nM 8.05
CHEMBL14182 Ki = 9.0 nM 8.05
CHEMBL121393 Ki = 9.0 nM 8.05