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Assay Detail

CHEMBL657191

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Binding
Inhibitory activity tested against human Cathepsin B
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cathepsin B (CHEMBL4072)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cyclic ketone inhibitors of the cysteine protease cathepsin K.
Marquis RW, Ru Y, Zeng J, Trout RE, LoCastro SM, Gribble AD, Witherington J, Fenwick AE, Garnier B, Tomaszek T, Tew D, Hemling ME, Quinn CJ, Smith WW, Zhao B, McQueney MS, Janson CA, D'Alessio K, Veber DF.
J Med Chem (2001) 44 : 725 -736
PubMed 11262083 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 5.91 7.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL350591 1 7.34
CHEMBL118449 1 6.36
CHEMBL423995 1 5.58
CHEMBL2371402 1 5.14
CHEMBL62239 1 5.11
CHEMBL162631 1 -
CHEMBL162389 1 -
CHEMBL61805 1 -
CHEMBL100563 1 -
CHEMBL301683 1 -
CHEMBL349823 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL350591 Ki = 46.0 nM 7.34
CHEMBL118449 Ki = 440.0 nM 6.36
CHEMBL423995 Ki = 2600.0 nM 5.58
CHEMBL2371402 Ki = 7300.0 nM 5.14
CHEMBL62239 Ki = 7800.0 nM 5.11
CHEMBL162631 Ki > 10000.0 nM -
CHEMBL162389 Ki > 10000.0 nM -
CHEMBL61805 Ki > 10000.0 nM -
CHEMBL100563 Ki > 1000.0 nM -
CHEMBL301683 Ki > 1000.0 nM -
CHEMBL349823 Ki > 10000.0 nM -